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BioSpace

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BioSpace

BioSpace

From sequence to scale: Gene editing’s new era in biologics manufacturing

July 10, 2026 9:29am 20 min

In this episode of Denatured, you’ll hear from Jack Crawford, CEO of Demetra, and Magnus Gustavsson, chief commercial officer at NorthX Biologics. We unpack the evolution of cell line development — CHO cells, targeted in...

Vertex carries M&A uptick into H2, IPOs and VC raises also grow, FDA on pace despite turmoil

July 08, 2026 2:00am 17 min

A surprising deal from Vertex Pharmaceuticals adds to Big Pharma’s acquisitive streak as Crinetics folds into the cystic fibrosis drugmaker. Meanwhile, IPOs and venture capital raises trend upward, but mostly for deriske...

Sentiment at BIO soars as FDA resets, dealmaking evolves; Amgen’s Tavneos in hot water

July 01, 2026 3:00am 22 min

The vibe at BIO 2026 in San Diego last week was overwhelmingly positive, with attendees observing noticeable changes at the FDA and an uptick in dealmaking and IPOs. Plus, a top medical journal this week retracted a pivo...

The Golden Triangle and the gaps: Rethinking UK biotech

June 25, 2026 2:00am 19 min

In this episode of Denatured, as part of our series on the European life sciences investment ecosystem, you’ll hear from Hakan Goker, managing director at M Ventures and Maina Bhaman, partner at Sofinnova Partners. We ex...

AbbVie keeps M&A rolling, FDA’s reversal train chugs along, BIO 2026 dispatch, more

June 24, 2026 2:00am 21 min

This year has been partly defined by a return to M&A. In the first quarter of 2026, biopharma spent nearly $47 billion in acquisitions across 19 deals, and this week, AbbVie notched another one for the second quarter, sc...

From fragile skin to living medicine: Lessons from RDEB

June 18, 2026 9:03am 21 min

In this episode of Denatured, you'll hear from Mark Lowdell, CSO & co-founder at INmuneBio Inc. and Vishwas Seshadri, CEO & director at Abeona Therapeutics. We examine how recessive dystrophic epidermolysis bullosa serve...

Moderna’s FDA adcomm, IPO mania, biopharma layoffs, more

June 17, 2026 2:00am 25 min

Moderna’s mRNA-based flu vaccine made headlines in February when the FDA declined to even review the application. Days later, the agency reversed course, setting a decision date for August and later scheduling an advisor...

Portugal, Spain and the new biotech frontier

June 10, 2026 6:00pm 20 min

In this episode of Denatured, as part of our series on the European life sciences investment ecosystem, you'll hear from Hannah Franklin, associate at Biovance Capital and Pablo Gabriel Cironi Lopez, director of life sc...

Lilly tees off with Novo at ADA, GSK’s $10.6B deal, FDA reform continues in Makary’s absence

June 10, 2026 2:00am 25 min

Everything came up roses for Eli Lilly at the American Diabetes Association, as the pharma boasted positive results for its new pill Foundayo and next-gen asset retatrutide—not just for weight loss but also for other ind...

Rethinking hair loss treatment

June 03, 2026 6:00pm 21 min

In this episode of Denatured, you'll be hearing from Daniel Gil, CEO of Pelage Pharmaceuticals and Francisco Ramírez-Valle, senior vice president of immunology discovery at Eli Lilly. We dive into the long-overlooked hai...

ASCO wins from RevMed, Akeso/Summit, more; plus more Lilly and more China; ADA on deck

June 03, 2026 4:48am 27 min

At the American Society of Clinical Oncology (ASCO) annual meeting in Chicago this past weekend, packed plenary sessions from Revolution Medicines and Summit Therapeutics’ Chinese partner Akeso stole the show. For RevMed...

France’s biotech ecosystem: science, capital and scale

May 28, 2026 2:00am 21 min

In this episode of Denatured, as part of our series on the European life sciences investment ecosystem, you'll be hearing from Ksenija Pavletic, partner and chief commercial officer at Jeito Capital and Thierry Laugel, m...

Lilly wheels and deals, Moderna gets boost on hantavirus scare, ASCO excitement builds

May 27, 2026 2:00am 24 min

Eli Lilly has been as acquisitive as ever, striking five new deals in the past week alone. On Tuesday, the company dove into the deep end of vaccine development with three separate buys in the space. Outside of vaccines,...

Inside Germany’s biotech capital infrastructure and innovation engine

May 21, 2026 2:00am 23 min

In this episode of Denatured, as part of our series of the European life science investment ecosystem, you'll be hearing from Regina Hodits, managing director at Angelini Ventures and Sofia Ioannidou, VC partner at Ande...

FDA’s absent leaders, the millions pharma CEOs make, and pancreatic cancer’s momentum

May 20, 2026 2:00am 26 min

FDA Commissioner Marty Makary officially resigned last week following reports of his ouster. Then, the acting directors for the agency’s two main review units also left their posts, as did the FDA chief of staff and chie...

From MSCs to iPSCs: building the cell therapy future

May 14, 2026 2:00am 20 min

In this episode of Denatured, you'll be hearing from Miguel Forte, president of the International Society for Cell and Gene Therapy (ISCT), and John Ellis, co-founder & CEO of Trenchant Bios, speaking live from the ISCT ...

Makary’s out at FDA, Sanofi’s priority voucher issues, top exec pay

May 13, 2026 2:00am 15 min

Moments after recording this episode of The Weekly, FDA Commissioner Marty Makary announced his resignation. Reports first circulated last Friday that President Donald Trump had signed off on his ouster. The president in...

Fibrosis, IPF and the search for better therapies

May 07, 2026 2:00am 18 min

In this episode of Denatured, you'll be hearing from Georg Vo Beiske, CEO of Tribune Therapeutics and Jonas Hallén, co-founder & Chief Medical Officer of Calluna Pharma. We dive into IPF and fibrosis challenges, unpackin...

Pfizer, Lilly, more report Q1, FDA names acting CBER director and an ALS awakening

May 06, 2026 5:16am 22 min

First quarter earnings continue to roll in, with Pfizer, Eli Lilly, Amgen and more reporting in the past week. While Pfizer beat consensus estimates, it wasn’t enough for analysts, who had greater expectations for the Ne...

Pfizer, Lilly, more report Q1, FDA names acting CBER director and an ALS awakening

May 06, 2026 2:00am 26 min

First quarter earnings continue to roll in, with Pfizer, Eli Lilly, Amgen and more reporting in the past week. While Pfizer beat consensus estimates, it wasn’t enough for analysts, who had greater expectations for the Ne...

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