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Innovating Clinical Trials

Ciencia

Innovating Clinical Trials

Liam Eves and Ted Trafford

Ep 2.29: Lasagna's Law and Building Recruitment Forecasts You Can Actually Trust

July 10, 2026 5:00am 18 min

Every trial starts with a number on a slide,  patients needed, months allotted, a clean straight line on a chart. Liam and Ted pull that line apart in this episode, starting with Lasagna's Law: the 1970s observation that...

Ep. 2.25 The Burdens Still Breaking Clinical Trials: 50-Page Consents, Broken Tech, and Stolen CRCs

June 17, 2026 6:00am 15 min

In this episode, Ted  opens with a poem that captures the persistent, compounding burden on clinical trial sites: 50-page consents, non-functional tech, poached CRCs, financial holdbacks, and study designs that ask far t...

Ep 2.24 The Decision Threshold Matrix: Why Patient Motivation Isn't Fixed and What It Means for Trial Recruitment

June 10, 2026 6:00am 21 min

In this episode, Liam and Ted explore one of the most underexamined problems in clinical trial recruitment: patient motivation is not static. Drawing on real-world experience from a late-night participant funnel audit to...

Ep 2.23: Jill Fikowski on Why Participants Drop Out and What to Do About It (3/3)

May 21, 2026 6:00am 13 min

In the final episode of our three-part series with Jill Fikowski, founder and CEO of Changemark Research + Evaluation, we get into one of the most persistent problems in clinical research: retention.Jill unpacks why part...

Ep 2.22: Jill Fikowski on Designing Trials That Communities Actually Want to Join (2/3)

May 20, 2026 6:00am 21 min

In Part 2 of our conversation with Jill Fikowski, founder and CEO of Changemark Research + Evaluation, we get into what good community engagement actually looks like in practice not as a checkbox, but as a core design pr...

Ep 2.21: Jill Fikowski on on Substance Use, Stigma, and the Research That Actually Changed Policy (1/3)

May 19, 2026 6:00am 13 min

Jill Fikowski, founder and CEO of Changemark Research + Evaluation, brings 25+ years of lived and professional experience in substance use and mental health research. In this episode we cover her work on the SALOME trial...

ICT Ep 2.20: What Monty Python Can Teach Us About Clinical Trials

May 14, 2026 6:00am 12 min

Clinical trials don’t become complex overnight, they get there one added process at a time.In this episode, Ted and Liam break down why the industry is so effective at adding new layers, but rarely takes the time to remo...

ICT Ep 2.19: Everyone Has a Plan Until the Trial Starts

May 06, 2026 6:00am 12 min

A 5 AM wake-up call. A perfectly planned setup. And a moment that never delivered.In this episode, Liam and Ted use a story about a missed “blood moon” to explore a deeper truth in clinical trials: expectations don’t alw...

ICT Ep 2.18 What Recruitment Is Missing: Time, Trust, and a Cup of Tea

April 29, 2026 6:00am 13 min

What does it actually mean to put the patient first?In this episode, Liam and Ted explore the role of empathy and human connection in clinical trials. From rushed pre-screening calls to a powerful story of pausing a cons...

ICT Ep 2.17 Borrowing the F1 Playbook: What Formula One Gets Right That Clinical Trials Don't

April 16, 2026 6:00am 14 min

What makes a truly high-performing team?Inspired by the precision of Formula One pit crews, where the difference between winning and losing is measured in milliseconds, Ted and Liam explore what clinical trial teams can ...

ICT Ep. 2.16 Leading Teams That Take Risks and Deliver Results With Frank Watanabe (3/3)

April 13, 2026 6:00am 13 min

In Part 3 of 3, Liam and Ted continue their conversation with Frank Watanabe, CEO of Arcutis Biotherapeutics discussing work-life balance, building social capital, and management vs. leadership.The conversation explores ...

ICT Ep. 2.15 Innovation, Risk and Building Great Teams With Frank Watanabe (2/3)

April 09, 2026 6:00am 11 min

In Part 2 of 3, Liam and Ted continue their conversation with Frank Watanabe, CEO of Arcutis Biotherapeutics, focusing on what it takes to hire and build high-performing teams in high-risk environments.Frank shares how h...

ICT Ep. 2.14 From Navy Officer to CEO: The DNA of Leadership with Frank Watanabe (1/3)

April 07, 2026 1:00pm 15 min

In this episode, Liam and Ted sit down with Frank Watanabe, President and CEO of Arcutis Biotherapeutics, to explore his journey from a Navy officer to a biotech executive and the leadership principles established along ...

ICT Ep 2.13: The Hidden Complexity of Trial Feasibility

April 01, 2026 6:00am 20 min

A patient in a database is not a patient in a trial. So why do we keep treating feasibility like a headcount?Fresh from a week deep in feasibility work, Liam introduces four characters who show up and cause chaos in almo...

ICT Ep: 2.12: Dropping the Baton: Why Clinical Trial Handoffs Keep Failing

March 18, 2026 7:00am 13 min

In elite sports, races are often won or lost in the transition, and Liam and Ted argue that the same is true in clinical trials. Drawing on the precision of Olympic relay racing, they make the case that the handoff point...

ICT Ep 2.11: The Top 10 Signs Your Site Feasibility Process Is Off Track

March 11, 2026 4:00am 10 min

Using a David Letterman-inspired “Top 10” format, the conversation highlights common feasibility pitfalls faced by sponsors, CROs, and clinical trial sites, including overly complex questionnaires, unrealistic enrollment...

ICT Ep 2.10 Where Clinical Trials Break Down, Even With Good Teams

March 04, 2026 6:00am 18 min

Why do clinical trials struggle even when teams are experienced and well-intentioned?In this episode, Liam and Ted explore why these outcomes are rarely about individual performance and far more often about system-level ...

ICT EP 2.9: Designing Eligibility Criteria That Work in the Real World

February 18, 2026 5:00am 18 min

Eligibility criteria are meant to bring clarity to clinical trials, but in practice, they often do the opposite.In this episode of Innovating Clinical Trials, Liam and Ted unpack how poorly worded, ambiguous, or misalign...

ICT EP 2.8: The Cost of Fragmented Enrollment Ownership And Why Leadership Must Step In

February 11, 2026 3:00am 17 min

In this episode, Liam and Ted unpack why enrollment behaves more like an operating system rather than a standalone process. They explore the question of ownership, the role sponsors play through protocol design, and how ...

ICT EP 2.7: Rethinking How Sponsors Build Site Relationships

February 04, 2026 2:00am 12 min

In this episode of Innovating Clinical Trials, Liam and Ted explore why building strong relationships with clinical trial sites requires more than dedicated relationship teams, it requires fixing problems at their source...

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